Columbia University Researchers Discover On-off Switch For Chronic Pain
Chronic pain affects approximately 48 million people in the U.S. and current medications are either largely ineffective or have serious side effects. But researchers from Columbia University Medical Center have discovered a protein in nerve cells that acts as a switch for chronic pain, and have applied for a patent to develop a new class of drugs that will block chronic pain by turning this switch off. The discovery is published on the website of the journal Neuroscience, and will appear in the publication’s August issue.
Most prior attempts at alleviating chronic pain have focused on the “second order” neurons in the spinal cord that relay pain messages to the brain. It’s difficult to inhibit the activity of these neurons with drugs, though, because the drugs need to overcome the blood-brain ... See the complete post here
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